Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults

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Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults

Metheny, Leland (author): Univ Hosp Cleveland Med Ctr, Seidman Canc Ctr, 11100 Euclid Ave, Cleveland, OH 44122 USA.

Callander, Natalie S. (author): Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA.,Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.

Hall, Aric C. (author): Univ Wisconsin Hosp & Clin, Madison, WI 53792 USA.

Zhang, Mei-Jei (author): Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.

Bo-Subait, Khalid (author): Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.

Wang, Hai-Lin (author): Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.

Agrawal, Vaibhav (author): Stanford Univ, Sch Med, Dept Med, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA.

Samer Al-Homsi, A. (author): New York Univ Langone Hlth, New York, NY USA.,Columbia Univ, Dept Med, Irving Med Ctr, Bone Marrow Transplant & Cell Therapy Program, New York, NY USA.

Assal, Amer (author): Columbia Univ, Dept Med, Irving Med Ctr, Bone Marrow Transplant & Cell Therapy Program, New York, NY USA.,Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.;Univ Calgary, Calgary, AB, Canada.,Univ Maryland, Greenebaum Comprehens Canc Ctr, Dept Med, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.

Bacher, Ulrike (author): Univ Bern, Univ Hosp Bern, Inselspital, Dept Hematol, Bern, Switzerland.

Beitinjaneh, Amer (author): Univ Miami, Div Transplantat & Cellular Therapy, Miami, FL USA.

Bejanyan, Nelli (author): H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Minneapolis, MN USA.

Bhatt, Vijaya Raj (author): Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA.

Bredeson, Chris (author): Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada.;Ottawa Hosp Res Inst, Ottawa, ON, Canada.

Byrne, Michael (author): Vanderbilt Univ, Med Ctr, Nashville, TN USA.

Cairo, Mitchell (author): New York Med Coll, Dept Pediat, Div Pediat Hematol Oncol & Stem Cell Transplantat, Valhalla, NY 10595 USA.

Cerny, Jan (author): Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA.

DeFilipp, Zachariah (author): Massachusetts Gen Hosp, Hematopoiet Cell Transplant & Cellular Therapy Pr, Boston, MA 02114 USA.

Diaz Perez, Miguel Angel (author): Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain.

Freytes, César O. (author): Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.

Ganguly, Siddhartha (author): Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA.

Grunwald, Michael R. (author): Atrium Hlth, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.

Hashmi, Shahrukh (author): Mayo Clin, Dept Internal Med, Rochester, MN USA.;Sheikh Shakhbout Med City, Dept Med, Abu Dhavi, U Arab Emirates.

Hildebrandt, Gerhard C. (author): Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.

Inamoto, Yoshihiro (author): Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.

Kanakry, Christopher G. (author): NCI, Expt Transplantat & Immunotherapy Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.

Kharfan-Dabaja, Mohamed A. (author): Mayo Clin, Blood & Marrow Transplantat Program, Div Hematol Oncol, Jacksonville, FL 32224 USA.;Univ Calgary, Calgary, AB, Canada.

Lazarus, Hillard M. (author): Case Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Cleveland, OH 44106 USA.

Lee, Jong Wook (author): Catholic Univ Korea, Seoul St Marys Hosp, Div Hematol, Seoul, South Korea.

Nathan, Sunita (author): Rush Univ, Med Ctr, Sect Bone Marrow Transplant & Cell Therapy, Chicago, IL 60612 USA.

Nishihori, Taiga (author): H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplant & Cellular Immunot, Minneapolis, MN USA.

Olsson, Richard F. (author): Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden

Ringdén, Olov (author): Karolinska Institutet,Karolinska Inst, Translat Cell Therapy Grp, CLINTEC Clin Sci Intervent & Technol, Stockholm, Sweden.

Rizzieri, David (author): Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.

Savani, Bipin N. (author): Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.

Savoie, Mary Lynn (author)

Seo, Sachiko (author): Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan.,NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.

van der Poel, Marjolein (author): Maastricht Univ, Med Ctr, Maastricht, Netherlands.

Verdonck, Leo F. (author): Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands.

Wagner, John L. (author): Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19107 USA.

Yared, Jean A. (author): Univ Maryland, Greenebaum Comprehens Canc Ctr, Dept Med, Blood & Marrow Transplantat Program,Div Hematol O, Baltimore, MD 21201 USA.

Hourigan, Christopher S. (author): NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.

Kebriaei, Partow (author): Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.

Litzow, Mark (author): Mayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.

Sandmaier, Brenda M. (author): Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.

Saber, Wael (author): Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.

Weisdorf, Daniel (author): Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA.

de Lima, Marcos (author): Univ Hosp Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.

Freytes, EO (author)

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Univ Hosp Cleveland Med Ctr, Seidman Canc Ctr, 11100 Euclid Ave, Cleveland, OH 44122 USA Univ Wisconsin, Carbone Canc Ctr, Madison, WI USA. (creator_code:org_t)

Elsevier, 2021
2021
English.
In: Transplantation and Cellular Therapy. - : Elsevier. - 2666-6375 .- 2666-6367. ; 27:11, s. 923.e1-923.e12

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Patients who develop therapy-related myeloid neoplasm, either myelodysplastic syndrome (t-MDS) or acute myelogenous leukemia (t-AML), have a poor prognosis. An earlier Center for International Blood and Marrow Transplant Research (CIBMTR) analysis of 868 allogeneic hematopoietic cell transplantations (allo-HCTs) performed between 1990 and 2004 showed a 5-year overall survival (OS) and disease-free survival (DFS) of 22% and 21%, respectively. Modern supportive care, graft-versus-host disease prophylaxis, and reduced-intensity conditioning (RIC) regimens have led to improved outcomes. Therefore, the CIBMTR analyzed 1531 allo-HCTs performed in adults with t-MDS (n = 759) or t-AML (n = 772) between and 2000 and 2014. The median age was 59 years (range, 18 to 74 years) for the patients with t-MDS and 52 years (range, 18 to 77 years) for those with tAML. Twenty-four percent of patients with t-MDS and 11% of those with t-AML had undergone a previous autologous (auto-) HCT. A myeloablative conditioning (MAC) regimen was used in 49% of patients with t-MDS and 61% of patients with t-AML. Nonrelapse mortality at 5 years was 34% (95% confidence interval [CI], 30% to 37%) for patients with t-MDS and 34% (95% CI, 30% to 37%) for those with t-AML. Relapse rates at 5 years in the 2 groups were 46% (95% CI, 43% to 50%) and 43% (95% CI, 40% to 47%). Five-year OS and DFS were 27% (95% CI, 23% to 31%) and 19% (95% CI, 16% to 23%), respectively, for patients with t-MDS and 25% (95% CI, 22% to 28%) and 23% (95% CI, 20% to 26%), respectively, for those with t-AML. In multivariate analysis, OS and DFS were significantly better in young patients with low-risk t-MDS and those with t-AML undergoing HCT with MAC while in first complete remission, but worse for those with previous auto-HCT, higher-risk cytogenetics or Revised International Prognostic Scoring System score, and a partially matched unrelated donor. Relapse remains the major cause of treatment failure, with little improvement seen over the past 2 decades. These data mandate caution when recommending allo-HCT in these conditions and indicate the need for more effective antineoplastic approaches before and after allo-HCT.

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By the author/editor: Metheny, Leland; Callander, Natal ...; Hall, Aric C.; Zhang, Mei-Jei; Bo-Subait, Khali ...; Wang, Hai-Lin; show more...; Agrawal, Vaibhav; Samer Al-Homsi, ...; Assal, Amer; Bacher, Ulrike; Beitinjaneh, Ame ...; Bejanyan, Nelli; Bhatt, Vijaya Ra ...; Bredeson, Chris; Byrne, Michael; Cairo, Mitchell; Cerny, Jan; DeFilipp, Zachar ...; Diaz Perez, Migu ...; Freytes, César O ...; Ganguly, Siddhar ...; Grunwald, Michae ...; Hashmi, Shahrukh; Hildebrandt, Ger ...; Inamoto, Yoshihi ...; Kanakry, Christo ...; Kharfan-Dabaja, ...; Lazarus, Hillard ...; Lee, Jong Wook; Nathan, Sunita; Nishihori, Taiga; Olsson, Richard ...; Ringdén, Olov; Rizzieri, David; Savani, Bipin N.; Savoie, Mary Lyn ...; Seo, Sachiko; van der Poel, Ma ...; Verdonck, Leo F.; Wagner, John L.; Yared, Jean A.; Hourigan, Christ ...; Kebriaei, Partow; Litzow, Mark; Sandmaier, Brend ...; Saber, Wael; Weisdorf, Daniel; de Lima, Marcos; Freytes, EO; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Articles in the publication: Transplantation ...

By the university: Uppsala University; Karolinska Institutet

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Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults

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